Hitting the sweet spot for lymphoma.

" truly exist for lymphocyte extravasa-tions, and future investigation will be needed to resolve this issue. Additionally, Bajenoff and Germain recently reported that the re-modeling of the conduit system that allows efficient delivery of soluble antigens from the periphery to FDC accompanies B-cell follicle development. It remains to be determined what role, if any, LT␣␤ expression by B cell may contribute to this process. 15 Finally, the observation presented in this report also poses the possibility that a similar paradigm may exist to accomplish LN resolution following viral clearance. As mRNA levels of LT␣ and LT␤ diminish after day 4 after LCMV infection, there is a concomitant decrease in the number of B cells in the LN. 13 Understanding molecular and cellular identities involved in the restoration of LN architecture and lymphocyte homeostasis following viral insults will add to our knowledge base in understanding the complex communication network regulating immune responses in vivo. The current work by Kumar et al furthers our understanding in a rapidly evolving cutting-edge field and highlights the symbiotic relationship between anatomy and function in immunobiology. 1 Conflict-of-interest disclosure: The author declares no competing financial interests. ■ REFERENCES 1. Kumar V, Scandella E, Danuser R, et al. Global lym-phoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. enhance immunity by guiding naive CD8ϩ T cells to sites of CD4ϩ T cell-dendritic cell interaction. Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development. role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. A chemokine-driven positive feedback loop organizes lymphoid follicles. of lymphoid organ integrity through the interaction of lym-phoid tissue-inducer cells with stroma of the T cell zone. cell networks regulate lymphocyte entry, migration, and territorial-ity in lymph nodes.cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Anyone who has ever played a racket sport, baseball, cricket, and/or golf can attest to experiencing the " sweet spot " —that place where the least jolt is felt on contact. In this issue of Blood, Chen et al show how sugar-decorated liposomes can be used to deliver doxorubicin in a targeted manner to malignant B cells, thus limiting the systemic jolt of this potent cytotoxic …